Albert Wesker

The second greatest bad guy in existence.

The mastermind who is in some way responsible for pretty much the entire Resident Evil series, Wesker is never seen without his trademark black sunglasses and slick hairdo.

Is tied with Revolver Ocelot for the title of 'World's biggest double crossing backstabbing basard', but beats out his russian counterpart in the overall badass stakes by being stabbed through the lungs by a tyrant on purpose and still coming back for more.

Wesker is responsible for one of the wisest pieces of advice ever given. Namely "Never trust anyone who wears dark glasses, indoors, at night."

(Oh, BTW, the greatest bad guy in existence is SHODAN from System Shock. But she's never made it into a contest. Revolver Ocelot is third. Sephiroth is somewhere in three figure territory)